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serum sickness
Serum sickness in humans is a reaction to proteins in antiserum derived from a non-human animal source, occurring 4–10 days after exposure. It is a type of hypersensitivity, specifically immune complex hypersensitivity (type III). The term serum sickness-like reaction (SSLR) is occasionally used to refer to similar illnesses that arise from the introduction of certain non-protein substances. It was first characterized by Clemens von Pirquet and Béla Schick in 1906.
==Causes==
When an antiserum is given, the human immune system can mistake the proteins present for harmful antigens. The body produces antibodies, which combine with these proteins to form immune complexes. These complexes precipitate, enter the walls of blood vessels, and activate the complement cascade, initiate an inflammatory response and consuming much of the available C3. The result is a leukocytoclastic vasculitis. They can also cause more reactions resulting in typical symptoms of serum sickness. This results in hypocomplementemia, a low C3 level in serum.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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